Sileo Rx
3mL Syringe
Starting At
$30.99
Sileo Rx
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Guaranteed lowest authorized price. Learn more.
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Usually ships the same weekday before 3pm CT with veterinary approval.
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Requires veterinary authorization.
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Your pet's veterinarian will provide directions for use.
What is Sileo for Dogs?
- Some of the most common noises that cause fear and anxiety disorders in dogs include thunderstorms, fireworks, traffic, construction, and loud music.
- Sileo contains the sedative Dexmedetomidine, which at a low dose to help calm dogs down, without heavy sedation, so they can keep fully functional.
- Sileo is an oral gel that absorbs through the mucous membranes in the mouth and is applied between the cheek and gum line.
- Sileo starts working in 30 to 60 min and lasts 2 to 3 hours.
Why do dogs use Sileo?
- Sileo is a prescription gel given on the gums that helps dogs that suffer from anxiety and behavioral problems caused by noises (noise aversion).
What else should I know about Sileo?
- The Sileo syringe should be discarded within 4 weeks after opening.
- Pregnant women should avoid handling Sileo.
What problems could my dog have with Sileo?
- Additional doses should be given only if your veterinarian recommends it, it has been 2 to 3 hours since the last dose, your dog is still showing signs of fear and anxiety, and your dog is not sleepy from the first dose.
- Side effects of Sileo include vomiting, diarrhea, drowsiness, low energy, slow heart rate, and decreased breathing.
What is in Sileo?
- Sileo contains the drug Dexmedetomidine.
- Dexmedetomidine works as a sedative and pain reliever.
Will I get what I see in the picture?
- Sileo is a brand name. You will receive the exact brand that you request.
Is it important for my dog to finish all of the Sileo?
- Dogs may use Sileo for different lengths of time. Please consult your veterinarian if you have any questions.
How do you use Sileo?
- Sileo absorbs through the mucous membranes in the mouth.
- Dots of the Sileo gel are applied between the cheek and gum line.
- Wear gloves when handling Sileo to protect yourself.
- It is important to make sure the dosing ring is locked in place before administering Sileo to prevent an accidental overdose.
Sileo Dosing Video:
Sileo Further Dosing Video:
Review Summary
24 total reviews
Rated 4.63 out of 5 stars
100% of respondents would recommend this to a friend
Ratings Distribution
19 5 star reviews
2 4 star reviews
2 3 star reviews
1 2 star reviews
0 1 star reviews
Most Liked Positive Review
Great product for dogs with noise induced anxiety!
We have a Lhasa who's terrified of thunder and fireworks. We have tried giving her Melatonin as well as have her wear the Thundershirt but after a while she would get accustomed to it and her anxiety would return. We gave her the amount of Sileo prescribed by her veterinarian and instead of shaking like a leaf like she normally would, she was calm and went to sleep comfortably. We've given this ahead of time when we knew a storm was coming (as well as on NYE) and given it once the storm was already over us. In both cases it worked in keeping her calm and reducing her noise induced anxiety to almost zero. We did not notice any adverse reactions to this product.
Most Liked Negative Review
Ok for sileo
I have a 13 yr old lab that any of the usual meds have had disappointing results. The fireworks were quieter this year but my neighbor had illegals. It took a second dose to get him yo sleep plus a little extra. With his size that was it.i expected better results
Reviews
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Sileo helps my dog manage stress during storms.
From UndisclosedComments about SileoMy dog gets very nervous during wind or snow storms when rain and sleet are pelting the house, or ice is sliding off the roof. Sileo helps her deal with these stressful times.-
![Sileo helps my dog manage stress during storms.]()
Belle and Angus
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Would highly recommend for anxiety
From UndisclosedComments about SileoWorked great my puppy is slot calmer in rain stroms. I was a little skeptical at first but the first time we trued it it worked Great!!!!!! -
Best anxiety/stress med EVER!
From UndisclosedComments about SileoWe've tried CBD's, and stress shirts for our dog and this is the only medication that actually works and calms him during thunderstorms in Florida. Highly recommend if you have a dog with high anxiety! -
STORMS BEWARE, SILEO IS HERE TO SAVE THE DAY AND THE STRESS
From UndisclosedComments about SileoABSOLUTELY THE BEST PRODUCT ON THE MARKET THAT OUR VET SUGGESTED FOR BOTH MY ENGLISH BULLDOG LUNCHBOX AND BOXER GIRL POPSICLE WHO ARE BOTH EXTREMELY STORM REACTIVE. EASY TO APPLY, WORKS WELL WITHIN 30 MINS AND LASTS THROUGH THE STORM OR ALSO MAY GIVE ANOTHER APPLICATION AFTER 4 HOURS. SOME OF MY PET CLIENTS HAVE ALSO USED IT WITH GOOD RESULTS. I SHOP AROUND FOR THE BEST PRICES AS THIS MEDICATION OBTAINED THROUGH OUR VET WAS ALMOST 3X THE COST VS ONLINE PURCHASE. DOGS ARE RESTED, LESS STRESSED, CONTENT AS WE RIDE OUT THE STORM FOR THIS MOST RECENT PURCHASE OF 6 SYRINGES VET RX DIRECT KNOCKED IT OUT OF THE PARK ON PRICING -
Second year using this will be using again next year.
From UndisclosedComments about SileoWorks really well and super quickly for fireworks. -
I love this product, so easy on my pups!
From UndisclosedComments about Sileoprescribed for noise aversion, I love this product. It is easy to administer, works fast usually within ten minutes. Working this fast I don't have to watch my furbabies who are terrified of thunder and fireworks either be 'drugged' all day based on a weather report or have to wait 30 to 40 minutes for the pill or capsule to take effect. If the thunderstorm has not moved out I can administer additional and I don't have to watch my sedated dog the rest of the day if the thunderstorm does move out. It wears off rapidly compared to a pill or capsule. You administer it between gums and cheek so they don't have to swallow it. The only disadvantage is the entire tub should be used within two weeks of opening. I would love to have it come in a smaller amount, but I have to pups so I only order around spring for storms and the holidays for which fireworks are used. It usually takes care of the bulk of the meds. GREAT product! -
Great pet Rx service, Penny's Sileo works for her!
From UndisclosedComments about SileoMy sweet dog , Penny Grace has a terrible response to thunderstorms. She is so stressed by regular daily noises, such as glasses or plates being placed in dishwasher. This medication was offered and at first I was reluctant because it was so new, but the tranquilizers, and Thundershirt was not working. Sileo has been a "miracle" for my dog. Correct timing before the storm, and combining with the diazepam tablet medication greatly reduces her reactions. It has proven to not be troublesome for Penny, by that I mean no side effects. I found the best price here and have ordered two at a time. Any medication,just like for us, has to be considered by your vet, and their knowledge and recommendation for your dog, some heart and other conditions would make Sileo, perhaps not the best choice. I have received great service from Vet Rx Direct. My last order was on a brief hold, needed a refill okay from Dr Stacey, as soon as I communicated the need to ship, storms forecasted in my region, the Sileo was shipped and received in time for Penny,!-
![Great pet Rx service, Penny's Sileo works for her!]()
Sweet Penny Grace, rescue, Paws in Prison, AR dog. Lab, and super dog mix. ❤️
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Great but pricey
From UndisclosedComments about SileoIt's a great product in as far as it works really well. It does take a good 20-30 minutes to start working though and it does not last more than 2-3 hours. Most thunderstorms don't last that long but if they do, you are going to need another dose, and it is really expensive. -
I try to keep Sileo on hand during the thunder storms.
From UndisclosedComments about SileoMy little dog gets very upset when there is a thunder storm or fireworks. I give her Sileo and it calms her down real good. -
I would buy this product again
From undisclosedComments about SileoUse this with my Yorkie during thunderstorms. Great product and VetRx are easy to work with
Displaying Reviews 1 - 10
Q & A
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It says Sileo is to help with noise. My vet mentioned Sileo to me to help with my dog's anxiety when he needs to be in the car. His anxiety is caused by being in the car (even if the car isn't running), not noise from the car ride/traffic. Is Sileo likely to help for this or was I guided to a medicine that won't help??
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Sileo is FDA approved for the treatment of noise aversion in dogs. Under the direction and guidance of a veterinarian, Sileo is also used extra-label or off-label to reduce fear and anxiety during veterinary examinations. It contains the active ingredient Dexmedetomidine that works as a sedative and pain reliever. If your dog is still showing signs of anxiety 2-3 hours after administration then please speak with your veterinarian regarding additional doses and/or an alternative product.
Verified Answer
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Why does the medication need to be thrown away 4 weeks after opening the syringe??
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The manufacturer of Sileo for Dogs lists the beyond-use date as 4 weeks after the syringe is opened due to stability and sterility concerns for the medication after that time. Beyond 4 weeks, the manufacturer cannot guarantee the medication will be effective or uncontaminated by bacteria and other microbes.
Verified Answer
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I have a dog who takes phenobarbital for seizures, I need an additional medication I can give him for fireworks/storms. Can this be taken with the phenobarbital??
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According to Plumb’s Veterinary Drugs, Sileo should be used with caution in animals that have or are prone to developing seizures. The active ingredient in Sileo, Dexmedetomidine, was shown to lower the seizure threshold in animal studies. In combination, a dose reduction of both Phenobarbital and Sileo may be needed due to the potential additive effects of these medications combined. Please contact your Veterinarian to see if Sileo is safe for your dog's specific situation.
Verified Answer
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I used the correct dosage per the chart for my dog (4 dots) and administered it correctly but I saw no change in her during an event with very loud noises. Her weight is a little more than in the middle range for 4 dots and my question is, will giving her 5 dots help her better but still not make her drowsy? This is an event she participates in.?
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Would like more details on how is it administered. Thank you.?
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Please see the administration videos and document available in the More Info section on our website. If you have additional questions please give us a call.
Verified Answer
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I have a 40lb dog, which would be 4 doses/syringe. If I only use 1 dose, how long can I store the other 3 doses and how would they be stored??
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Sileo syringes are recommended to be used within two weeks of opening the syringe. Following the use of the first dose, the syringe can be stored in its original packaging at a controlled room temperature of 68-77 degrees Fahrenheit, as well as temperatures through 59-86 degrees Fahrenheit for a limited amount of time.
Verified Answer
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I purchased two tubes of silo gel for my dog the insert says it's supposed to be a clear or white Crystaline in color and both tubes or green color gel is this product so good thank you?
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The products you received are the correct color. Sileo Gel is is a teal-green translucent color. The white, crystalline substance referred to in the insert is the active ingredient, dexmedetomidine, which is dissolved in the green-teal gel for administration.
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Displaying Questions 1 - 7
