Sileo Rx
3mL Syringe
Starting At
$32.98
Sileo Rx
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Guaranteed lowest authorized price. Learn more.
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Usually ships the same weekday before 3pm CT with veterinary approval.
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Requires veterinary authorization.
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Your pet's veterinarian will provide directions for use.
What is Sileo for Dogs?
- Some of the most common noises that cause fear and anxiety disorders in dogs include thunderstorms, fireworks, traffic, construction, and loud music.
- Sileo contains the sedative Dexmedetomidine, which at a low dose to help calm dogs down, without heavy sedation, so they can keep fully functional.
- Sileo is an oral gel that absorbs through the mucous membranes in the mouth and is applied between the cheek and gum line.
- Sileo starts working in 30 to 60 min and lasts 2 to 3 hours.
Why do dogs use Sileo?
- Sileo is a prescription gel given on the gums that helps dogs that suffer from anxiety and behavioral problems caused by noises (noise aversion).
What else should I know about Sileo?
- The Sileo syringe should be discarded within 4 weeks after opening.
- Pregnant women should avoid handling Sileo.
What problems could my dog have with Sileo?
- Additional doses should be given only if your veterinarian recommends it, it has been 2 to 3 hours since the last dose, your dog is still showing signs of fear and anxiety, and your dog is not sleepy from the first dose.
- Side effects of Sileo include vomiting, diarrhea, drowsiness, low energy, slow heart rate, and decreased breathing.
What is in Sileo?
- Sileo contains the drug Dexmedetomidine.
- Dexmedetomidine works as a sedative and pain reliever.
Will I get what I see in the picture?
- Sileo is a brand name. You will receive the exact brand that you request.
Is it important for my dog to finish all of the Sileo?
- Dogs may use Sileo for different lengths of time. Please consult your veterinarian if you have any questions.
How do you use Sileo?
- Sileo absorbs through the mucous membranes in the mouth.
- Dots of the Sileo gel are applied between the cheek and gum line.
- Wear gloves when handling Sileo to protect yourself.
- It is important to make sure the dosing ring is locked in place before administering Sileo to prevent an accidental overdose.
Sileo Dosing Video:
Sileo Further Dosing Video:
Review Summary
24 total reviews
Rated 4.63 out of 5 stars
100% of respondents would recommend this to a friend
Ratings Distribution
19 5 star reviews
2 4 star reviews
2 3 star reviews
1 2 star reviews
0 1 star reviews
Most Liked Positive Review
Great product for dogs with noise induced anxiety!
We have a Lhasa who's terrified of thunder and fireworks. We have tried giving her Melatonin as well as have her wear the Thundershirt but after a while she would get accustomed to it and her anxiety would return. We gave her the amount of Sileo prescribed by her veterinarian and instead of shaking like a leaf like she normally would, she was calm and went to sleep comfortably. We've given this ahead of time when we knew a storm was coming (as well as on NYE) and given it once the storm was already over us. In both cases it worked in keeping her calm and reducing her noise induced anxiety to almost zero. We did not notice any adverse reactions to this product.
Most Liked Negative Review
Ok for sileo
I have a 13 yr old lab that any of the usual meds have had disappointing results. The fireworks were quieter this year but my neighbor had illegals. It took a second dose to get him yo sleep plus a little extra. With his size that was it.i expected better results
Reviews
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For Treating Loud Noises
From undisclosedComments about SileoGood for 4th of July. Make sure your dog does not drink water or eat 15 minutes after application so that the medicine may dissolve by the gums and jawline. -
I would order again
From undisclosedComments about SileoGreat service -
A must for July 4
From undisclosedComments about SileoFinally, after 10 years of having my dog, we were both able to enjoy July 4. I have tried everything through the years, and nothing worked until this. An absolute must for dogs terrified of fireworks!! Thank You!! -
Def worth a try!!
From undisclosedComments about SileoI've used every product out there for my dog and her fear of fireworks and thunder storms. This product has hands down been the best I've used! She doesn't get drunk like on it either. She just calms down and is able to sleep through them. I highly recommend this product -
Ok for sileo
From undisclosedComments about SileoI have a 13 yr old lab that any of the usual meds have had disappointing results. The fireworks were quieter this year but my neighbor had illegals. It took a second dose to get him yo sleep plus a little extra. With his size that was it.i expected better results -
Mild results at best
From undisclosedComments about SileoI used this for the 4th of July for my dog's fireworks anxiety. It appeared to work well for about an hour. After that he spent the next 3 hours barking and trying to hide. I will try something else next time. -
I will buy this product again.
From undisclosedComments about SileoThe Sileo really helps my dog calm down during a storm. -
Works for thunderstorms and fireworks
From undisclosedComments about SileoHad gotten this from my vet in the past, but they don't always stock it. My vet recommended VetRx direct and wrote a prescription. So easy. This works better than anything else the vet had prescribed. It's quick acting (read instructions carefully) and calms my dog during storms and firecracker season. Be sure to give proper dosage and pay attention to the # of spaces on syringe. Also be sure to wear gloves (you can buy a box of 10 or so at most discount stores. Do not give more than dog's weight calls for.If you give too much,don't panic, call your vet. -
Works amazingly on overly anxious dogs and fireworks!
From undisclosedComments about SileoMy dog is overly anxious with fireworks and storms to the point where even the two pills my vet has prescribed along with a dark room and a loud tv still has him pacing, shaking and drooling. This has helped tremendously. I still give him one pill early in the morning to mellow him out while the noise is low and start giving him this before I expect noise to start and he no longer runs from closet to closet. He still notices the noise and reacts slightly but it's not nearly as heartbreaking as when he's terrified and running every which way. I will continue to buy this for any loud holiday. Thank you!!! -
Yes I will keep this mediation in stock!
From undisclosedComments about SileoAwesome product!! 😍 Helps calm my German Shepherd in minutes! Highly recommended!! -
Displaying Reviews 11 - 20
Q & A
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It says Sileo is to help with noise. My vet mentioned Sileo to me to help with my dog's anxiety when he needs to be in the car. His anxiety is caused by being in the car (even if the car isn't running), not noise from the car ride/traffic. Is Sileo likely to help for this or was I guided to a medicine that won't help??
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Sileo is FDA approved for the treatment of noise aversion in dogs. Under the direction and guidance of a veterinarian, Sileo is also used extra-label or off-label to reduce fear and anxiety during veterinary examinations. It contains the active ingredient Dexmedetomidine that works as a sedative and pain reliever. If your dog is still showing signs of anxiety 2-3 hours after administration then please speak with your veterinarian regarding additional doses and/or an alternative product.
Verified Answer
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Why does the medication need to be thrown away 4 weeks after opening the syringe??
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The manufacturer of Sileo for Dogs lists the beyond-use date as 4 weeks after the syringe is opened due to stability and sterility concerns for the medication after that time. Beyond 4 weeks, the manufacturer cannot guarantee the medication will be effective or uncontaminated by bacteria and other microbes.
Verified Answer
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I have a dog who takes phenobarbital for seizures, I need an additional medication I can give him for fireworks/storms. Can this be taken with the phenobarbital??
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According to Plumb’s Veterinary Drugs, Sileo should be used with caution in animals that have or are prone to developing seizures. The active ingredient in Sileo, Dexmedetomidine, was shown to lower the seizure threshold in animal studies. In combination, a dose reduction of both Phenobarbital and Sileo may be needed due to the potential additive effects of these medications combined. Please contact your Veterinarian to see if Sileo is safe for your dog's specific situation.
Verified Answer
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I used the correct dosage per the chart for my dog (4 dots) and administered it correctly but I saw no change in her during an event with very loud noises. Her weight is a little more than in the middle range for 4 dots and my question is, will giving her 5 dots help her better but still not make her drowsy? This is an event she participates in.?
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Would like more details on how is it administered. Thank you.?
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Please see the administration videos and document available in the More Info section on our website. If you have additional questions please give us a call.
Verified Answer
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I have a 40lb dog, which would be 4 doses/syringe. If I only use 1 dose, how long can I store the other 3 doses and how would they be stored??
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Sileo syringes are recommended to be used within two weeks of opening the syringe. Following the use of the first dose, the syringe can be stored in its original packaging at a controlled room temperature of 68-77 degrees Fahrenheit, as well as temperatures through 59-86 degrees Fahrenheit for a limited amount of time.
Verified Answer
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I purchased two tubes of silo gel for my dog the insert says it's supposed to be a clear or white Crystaline in color and both tubes or green color gel is this product so good thank you?
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The products you received are the correct color. Sileo Gel is is a teal-green translucent color. The white, crystalline substance referred to in the insert is the active ingredient, dexmedetomidine, which is dissolved in the green-teal gel for administration.
Verified Answer
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Displaying Questions 1 - 7
