The NexGard brand products are a set of effective and convenient solutions for dog and cat owners seeking comprehensive parasite protection for their pets. For dogs, NexGard PLUS (afoxolaner, moxidectin, and pyrantel) provides monthly defense against fleas, ticks, heartworm disease, roundworms, and hookworms in dogs. The delicious beef-flavored soft chew makes it easy to administer. For cats, NexGard COMBO (esafoxolaner, eprinomectin, and praziquantel) offers a topical solution that safeguards against fleas, ticks, heartworm disease, roundworms, hookworms, and tapeworms, making it the first of its kind. The easy-to-apply topical solution ensures full spectrum protection. NexGard (afoxolaner) for dogs kills fleas and ticks and is FDA-approved and indicated to prevent Lyme Disease infections by killing black legged ticks.

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Frequently Asked Questions

NexGard®  is a prescription flea and tick preventative for dogs that contains the insecticide afoxolaner. NexGard kills fleas and ticks for 1 month and prevents Lyme disease infections by killing black-legged ticks.

NexGard and NexGard PLUS chewables are labeled for dogs and puppies at least 8 weeks of age and weighing at least 4 pounds. NexGard Combo can be used on cats and kittens 8 weeks of age and older.

After administration of NexGard, fleas will begin to die after 4 hours and ticks will begin to die in 12 hours or longer to fall off your animal.

The active ingredient in NexGard, afoxolaner, is an insecticide that kills fleas and ticks by overstimulating the nervous system of the parasite.


NexGard PLUS chewable contains three active ingredients: Afoxolaner, Moxidectin, and pyrantel. NexGard PLUS provides 1 month of protection from:

  • Heartworm disease.
  • Adult fleas, black-legged ticks, brown dog ticks, American dog ticks, and lone star ticks.
  • Roundworm and hookworm.

NexGard (afoxolaner) kill fleas and ticks. NexGard PLUS (afoxolaner, moxidectin, and pyrantel) prevents heartworm disease and kills fleas, ticks, roundworms, and hookworms. NexGard Combo (esafoxolaner, eprinomectin, praziquantel) protects against heartworm disease and kills fleas, ticks, roundworms, hookworms, and tapeworms.

Yes, NexGard kills adult fleas and ticks and prevents infestations for one month.

Yes, NexGard, NexGard Combo, and NexGard PLUS require a prescription from your licensed veterinarian dated within the last 12 months. After you place your order, we will contact your veterinarian’s office directly to confirm the prescription, and then we’ll ship your order.

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